F2r - coagulation factor II (thrombin) receptor Gene

Rattus norvegicus

Also known as Par1; TRGPC

Gene ID: 25439 | Gene type: protein coding

About F2r

Primary_assembly 2: 26,868,404-26,885,870 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 330 orthologues, 14 paralogues and is associated with 18 phenotypes. Biased expression in Lung (RPKM 362.8), Adrenal (RPKM 23.8) and 9 other tissues.

Summary

Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; positive regulation of cytosolic calcium ion concentration; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]

F2r Products(1)

mRNA	Protein	Name
NM_012950.2	NP_037082.2	proteinase-activated receptor 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12372796	RGD
involved in establishment of synaptic specificity at neuromuscular junction	IDA IDA: Inferred from direct assay	12815704	RGD
involved in negative regulation of glomerular filtration	IDA IDA: Inferred from direct assay	12644441	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11919511	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12644441	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12372796	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15145074	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12372796	RGD
involved in positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	14699501	RGD
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	12644441	RGD
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	15145074	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuromuscular junction	IDA IDA: Inferred from direct assay	12815704	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15145074	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	12815704	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2r Protein Structure

7tmA_PAR1

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 1

PAR-1	Thrombin receptor
coagulation factor II receptor	protease-activated receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04631	F2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04632	F2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04633	F2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2r	NCBI	NCBI:2149
Macaca fascicularis	F2r	NCBI	NCBI:102137130
Mus musculus	F2r	NCBI	NCBI:14062

Name
Email *

	Sorry, but the email address you supplied was invalid.