F2r - coagulation factor II (thrombin) receptor Gene

Rattus norvegicus

Also known as Par1; TRGPC

Gene ID: 25439 | Gene type: protein coding

About F2r

Primary_assembly 2: 26,868,404-26,885,870 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 330 orthologues, 14 paralogues and is associated with 18 phenotypes. Biased expression in Lung (RPKM 362.8), Adrenal (RPKM 23.8) and 9 other tissues.

Summary

Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; positive regulation of cytosolic calcium ion concentration; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]

F2r Products(1)

mRNA	Protein	Name
NM_012950.2	NP_037082.2	proteinase-activated receptor 1 precursor

F2r Protein Structure

7tmA_PAR1

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 1

PAR-1	Thrombin receptor
coagulation factor II receptor	protease-activated receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04631	F2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04632	F2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04633	F2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2r	NCBI	NCBI:2149
Macaca fascicularis	F2r	NCBI	NCBI:102137130
Mus musculus	F2r	NCBI	NCBI:14062

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