F2r - coagulation factor II (thrombin) receptor Gene

Mus musculus

Also known as Cf2r; Par1; ThrR

Gene ID: 14062 | Gene type: protein coding

About F2r

Chromosome 13: 95,738,311-95,754,995 reverse strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 330 orthologues, 16 paralogues and is associated with 54 phenotypes.

Summary

Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including negative regulation of Renin secretion into blood stream; positive regulation of intracellular signal transduction; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including regulation of interleukin-1 beta production; response to lipopolysaccharide; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including caveola; endosome; and platelet dense tubular network. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II Thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]

F2r Products(1)

mRNA	Protein	Name
NM_010169.4	NP_034299.2	proteinase-activated receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	20215560	MGI
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	20215560	MGI
enables G-protein beta-subunit binding	IDA IDA: Inferred from direct assay	20215560	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within dendritic cell homeostasis	IMP IMP: Inferred from mutant phenotype	18305483	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	18305483	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18305483	MGI
involved in negative regulation of renin secretion into blood stream	IDA IDA: Inferred from direct assay	21859963	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	20215560	MGI
acts upstream of or within positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	18305483	MGI
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20215560	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	18398001	MGI
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	21859963	MGI
acts upstream of or within regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18305483	MGI
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	25645137	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	18305483	MGI
acts upstream of or within thrombin-activated receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18398001	MGI
involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	21414931	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proteinase-activated receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04631	F2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04632	F2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04633	F2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2r	NCBI	NCBI:2149
Macaca fascicularis	F2r	NCBI	NCBI:102137130
Rattus norvegicus	F2r	NCBI	NCBI:25439

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