GFRA1 - Gfra1 GDNF family receptor alpha 1 Gene

Rattus norvegicus

Gene ID: 25454 | Gene type: protein coding

About GFRA1

Summary

Enables Integrin binding activity and neurotrophin receptor activity. Involved in several processes, including male gonad development; neuron projection development; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Part of plasma membrane protein complex and receptor complex. Used to study Parkinsonism. Biomarker of Parkinsonism; brain ischemia; and sciatic neuropathy. Orthologous to human GFRA1 (GDNF family receptor alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

GFRA1 Products(1)

mRNA	Protein	Name
NM_012959.2	NP_037091.1	GDNF family receptor alpha-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glial cell-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	25242331	RGD
enables integrin binding	IPI IPI: Inferred from physical interaction	18465789	RGD
enables neurotrophin receptor activity	IDA IDA: Inferred from direct assay	8674117	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10545102	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	16906542	RGD
involved in glial cell-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	25242331	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	15381258	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	22111653	RGD
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	21865882	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	15381258	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10545102	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16841166	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16086681	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16086681	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16841166	RGD
part of plasma membrane protein complex	IDA IDA: Inferred from direct assay	10545102	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	15709767	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GDNF family receptor alpha-1

GDNF family receptor alpha-1-like	GDNF receptor alpha
GDNF receptor alpha-1	GDNFR-alpha
GDNFR-alpha-1	GFR-alpha-1
Glial cell line-derived neurotrophic factor receptor alpha	RET ligand 1
TGF-beta-related neurotrophic factor receptor 1	glial cell l

GFRA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Gfra1	Q62997	SORL1	Homo sapiens	Q92673	Crosslink	23333276

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GFRA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76948	GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc)	Q62997-1 (D25-L445)	≥95%
HY-P76949	GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His)	Q62997-1 (D25-L445)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05386	GFRA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	GFRA1	NCBI	NCBI:2674
Canis familiaris	GFRA1	NCBI	NCBI:609114
Mus musculus	GFRA1	NCBI	NCBI:14585

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