MPV17L - MPV17 mitochondrial inner membrane protein like Gene

Homo sapiens

Also known as M-LPH; MLPH1; MLPH2; MPV17L1

Gene ID: 255027 | Gene type: protein coding

About MPV17L

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:15,395,754-15,413,271 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 256 orthologues and 3 paralogues. Broad expression in kidney (RPKM 1.8), duodenum (RPKM 1.5) and 20 other tissues.

Summary

Involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and Reactive Oxygen Species metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

MPV17L Products(2)

mRNA	Protein	Name
NM_001128423.2	NP_001121895.1	mpv17-like protein isoform 1
NM_173803.4	NP_776164.2	mpv17-like protein isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of hydrogen peroxide biosynthetic process	IDA IDA: Inferred from direct assay	22306510	GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22306510	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	16631601	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisome	IDA IDA: Inferred from direct assay	16631601	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPV17L Protein Structure

Mpv17_PMP22

0
100
196 a.a.

Protein Preferred Names

Protein Names

mpv17-like protein

M-LP homolog

Related Diseases

Diseases

Alias

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Autosomal Dominant Nonsyndromic Deafness 77

Dfna77

Autosomal Dominant Alport Syndrome

Alport Syndrome, Autosomal Dominant	Alport Syndrome Dominant Type
Renal Failure And Sensorineural Hearing Loss	Alport Syndrome, Dominant Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08632	MPV17L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MPV17L	RGD	RGD:2324483
Mus musculus	MPV17L	MGD	MGI:2135951

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