Sirpa - signal-regulatory protein alpha Gene

Rattus norvegicus

Also known as Bit; Ptpns1; SHPS-1

Gene ID: 25528 | Gene type: protein coding

About Sirpa

Summary

Enables GTPase regulator activity; Enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Sirpa Products(1)

mRNA	Protein	Name
NM_013016.3	NP_037148.3	tyrosine-protein phosphatase non-receptor type substrate 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase regulator activity	IMP IMP: Inferred from mutant phenotype	16055727	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8810330	RGD
enables protein binding involved in heterotypic cell-cell adhesion	IPI IPI: Inferred from physical interaction	16055727	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16055727	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16055727	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	12023387	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in cellular response to type II interferon	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in monocyte extravasation	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	21401967	RGD
involved in regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16055727	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	21401967	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type substrate 1

Brain immunoglobulin like protein with tyrosine - based activation motifs	CD172 antigen-like family member A
Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)	SHP substrate 1
brain Ig-like molecule with tyrosine-based activ

Recombinant Sirpa Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76072	SIRP alpha/CD172a Protein, Rat (HEK293, Fc)	BAA20368.1 (K32-N373)	≥95%
HY-P76073	SIRP alpha/CD172a Protein, Rat (HEK293, His)	P97710 (K32-N373)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12932	SIRPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirpa	NCBI	NCBI:140885
Macaca fascicularis	Sirpa	NCBI	NCBI:101926317
Mus musculus	Sirpa	NCBI	NCBI:19261

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