SIRPA - signal regulatory protein alpha Gene

Homo sapiens

Also known as BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

Gene ID: 140885 | Gene type: protein coding

About SIRPA

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,894,167-1,940,592 (from NCBI)

This gene has 4 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 60 phenotypes. Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several Other members of the SIRP family. These related genes are located in close proximity to each Other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

SIRPA Products(4)

mRNA	Protein	Name
NM_001040022.1	NP_001035111.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001040023.2	NP_001035112.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001330728.1	NP_001317657.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_080792.3	NP_542970.1	tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell-cell adhesion mediator activity	IPI IPI: Inferred from physical interaction	11509594	GOA
enables protein antigen binding	IPI IPI: Inferred from physical interaction	24026300	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17070842	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-12	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24026300	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	24511121	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11509594	GOA
involved in regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	11509594	GOA
involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	11509594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11509594	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24026300	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRPA Protein Structure

V-set

C1-set

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type substrate 1

CD172 antigen-like family member A

SIRPA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRPA	P78324	CD47	Homo sapiens	Q08722	Anti Tag CoIP	33961781
Intra	SIRPA	P78324	CD47	Homo sapiens	Q08722	ELISA	17070842

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIRPA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7405	SIRP alpha/CD172a Protein, Human (HEK293, His-Myc)	P78324-1 (E31-R370)	≥95%
HY-P7406	SIRP alpha/CD172a Protein, Human (HEK293, Fc)	P78324-1 (E31-R370)	≥95%
HY-P70484	SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, His)	CAA71403.1 (E31-R370)	≥95%
HY-P72412	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370)	≥95%
HY-P74546	SIRP alpha/CD172a Protein, Human (G75A, HEK293, His)	P78324-1 (E31-R370, G75A)	≥95%
HY-P76068	SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, His)	AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥95%
HY-P76069	SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, Fc)	AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥95%
HY-P77843	SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi)	P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H)	≥95%
HY-P77844	SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H)	≥95%
HY-P77846	SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	P78324-1 (E31-R370, S105P)	≥95%
HY-P77836	SIRP alpha V2/CD172a Protein, Human (HEK293, His)	AAH26692.1 (E31-R369)	≥95%
HY-P77837	SIRP alpha V2/CD172a Protein, Human (HEK293, Fc)	AAH26692.1 (E31-R369)	≥95%
HY-P77840	SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi)	AAH26692.1 (E31-R369)	≥95%
HY-P77841	SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi)	AAH38510.1 (E31-R369, H54L)	≥95%
HY-P77842	SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi)	AAH38510.1 (E31-R369, H54L)	≥95%
HY-P77845	SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi)	P78324-1 (E31-R370, S105P)	≥95%
HY-P77847	SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi)	ATD50864.1 (E31-R369, S44L, S50T, I52T, H54R, V57A)	≥95%
HY-P78211	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi)	P78324-1 (E31-R370)	≥95%

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath	Giant Cell Tumor Of Tendon Sheath
Giant Cell Tumor Of Tenosynovium	Giant Cell Tumour Of Tendon Sheath
Giant Cell Tumour Of Tenosynovium	Tenosynovial Giant Cell Tumour
Diffuse-Type Gct	Diffuse-Type Giant Cell Tumor
Pigmented Villonodular Synovitis	Tgct
Tsgct

Refractory Plasma Cell Neoplasm

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12932	SIRPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIRPA	MGD	MGI:108563
Rattus norvegicus	SIRPA	RGD	RGD:3449
Macaca fascicularis	SIRPA	NCBI	NCBI:101926317
Others	SIRPA	NCBI

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