2. Gene
  3. Slc5a1 - solute carrier family 5 member 1 Gene

Slc5a1 - solute carrier family 5 member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as SGLT1; SGLT1a

Gene ID: 25552 | Gene type: protein coding

About Slc5a1

Primary_assembly 14: 77,553,843-77,618,547 reverse strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 248 orthologues, 13 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 121.6) and Lung (RPKM 51.7).

Summary

Enables glucose:sodium symporter activity. Predicted to be involved in several processes, including alpha-glucoside transport; import across plasma membrane; and transepithelial water transport. Predicted to act upstream of or within glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane; brush border membrane; and cell-cell junction. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a1 Products(1)

mRNA Protein Name
NM_013033.2 NP_037165.1 sodium/glucose cotransporter 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D-glucose:sodium symporter activity IDA
IDA: Inferred from direct assay
15829715 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11831390 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
14986005 RGD
located in cell-cell junction IDA
IDA: Inferred from direct assay
17090404 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc5a1 Protein Structure

SLC5-6-like_sbd

SLC5-6-like_sbd: cl00456 (26 - 664)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
Protein Preferred Names Protein Names

sodium/glucose cotransporter 1

Na(+)/glucose cotransporter 1

Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)

high affinity sodium-glucose cotransporter

solute carrier family 5 (sodium/glucose cotransporter), member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13280 SLC5A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13281 Slc5a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13282 Slc5a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a1 NCBI NCBI:6523