Ppard - peroxisome proliferator-activated receptor delta Gene

Rattus norvegicus

Also known as Pparb

Gene ID: 25682 | Gene type: protein coding

About Ppard

Primary_assembly 20: 6,298,785-6,363,968 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 19 phenotypes. Biased expression in Heart (RPKM 3.7), Adrenal (RPKM 23.1) and 9 other tissues.

Summary

Enables NF-kappaB binding activity and fatty acid binding activity. Involved in several processes, including decidualization; negative regulation of collagen biosynthetic process; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard Products(1)

mRNA	Protein	Name
NM_013141.2	NP_037273.2	peroxisome proliferator-activated receptor delta

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	15728586	RGD
enables fatty acid binding	IDA IDA: Inferred from direct assay	12600885	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	15728586	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	12773104	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	12773104	RGD
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	12600885	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15754086	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16337160	RGD
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	18293166	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	17346664	RGD
involved in negative regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	18585719	RGD
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	18585719	RGD
involved in phospholipid biosynthetic process	IDA IDA: Inferred from direct assay	17148578	RGD
involved in positive regulation of epidermis development	IDA IDA: Inferred from direct assay	19675577	RGD
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	19965574	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	19965574	RGD
involved in proteoglycan metabolic process	IDA IDA: Inferred from direct assay	17140817	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	20233940	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18573863	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	19342198	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	19906781	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppard Protein Structure

NR_DBD_Ppar

NR_LBD_PPAR

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

peroxisome proliferator-activated receptor delta

peroxisome proliferator activator receptor beta

peroxisome proliferator activator receptor, delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121579	L-764406	Agonist	/	Unkown
HY-RS10922	PPARD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10923	Ppard Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10924	Ppard Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppard	NCBI	NCBI:5467

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