Htr5a - 5-hydroxytryptamine receptor 5A Gene

Rattus norvegicus

Also known as MR22; 5HT5A

Gene ID: 25689 | Gene type: protein coding

About Htr5a

Primary_assembly 4: 7,444,968-7,454,651 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 2 phenotypes. Restricted expression toward (RPKM 3.).

Summary

Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; hippocampus development; and response to estradiol. Located in several cellular components, including Golgi apparatus; perikaryon; and rough endoplasmic reticulum. Is integral component of postsynaptic specialization membrane. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Apr 2022]

Htr5a Products(1)

mRNA	Protein	Name
NM_013148.2	NP_037280.1	5-hydroxytryptamine receptor 5A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	7682702	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP IMP: Inferred from mutant phenotype	10861802	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	16572590	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17122082	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	17394137	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15282708	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	16082681	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr5a Protein Structure

7tm_GPCRs

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 5A

5-HT-5A	5-HT5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	REC17
serotonin receptor 5A

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06477	HTR5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06478	Htr5a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06479	Htr5a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr5a	NCBI	NCBI:3361

Name
Email *

	Sorry, but the email address you supplied was invalid.