Dbh - dopamine beta-hydroxylase Gene

Rattus norvegicus

Also known as DOPBHY

Gene ID: 25699 | Gene type: protein coding

About Dbh

Primary_assembly 3: 10,488,260-10,505,248 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward (RPKM 642.7).

Summary

Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular biogenic amine metabolic process; cellular response to manganese ion; and cellular response to nicotine. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; hypertension; mental depression; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products(1)

mRNA	Protein	Name
NM_013158.3	NP_037290.3	dopamine beta-hydroxylase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IMP IMP: Inferred from mutant phenotype	10573542	RGD
enables dopamine beta-monooxygenase activity	IDA IDA: Inferred from direct assay	15380000	RGD
enables dopamine beta-monooxygenase activity	IMP IMP: Inferred from mutant phenotype	11521740	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone development	IEP IEP: Inferred from expression pattern	20090303	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	19276553	RGD
involved in cellular response to nicotine	IEP IEP: Inferred from expression pattern	20827341	RGD
involved in norepinephrine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10573542	RGD
involved in octopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11521740	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	19079842	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	11914591	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16713504	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	19893991	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	18363828	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	19893991	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18783367	RGD
involved in response to ozone	IEP IEP: Inferred from expression pattern	19356678	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18522866	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20626387	RGD
involved in social behavior	IEP IEP: Inferred from expression pattern	15345906	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	20478367	RGD
located in axon	IDA IDA: Inferred from direct assay	15380000	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17572158	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18440151	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	19651110	RGD
located in varicosity	IDA IDA: Inferred from direct assay	19651110	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dbh Protein Structure

DOMON

Cu2_monooxygen

Cu2_monoox_C

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

dopamine beta-hydroxylase

Dopamine beta hydroxylase (dopamine beta-monooxygenase)

dopamine beta-monooxygenase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106004	Zamicastat	Inhibitor	99.93%	Phase 2
HY-14838	Etamicastat	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7204	4-Hydroxyderricin		99.97%	Unkown
HY-14838A	Etamicastat hydrochloride	Inhibitor	98.14%	Unkown
HY-156989	Butobendine	Inhibitor	/	Unkown
HY-RS03544	DBH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03545	Dbh Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03546	Dbh Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dbh	NCBI	NCBI:1621

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