Cckbr - cholecystokinin B receptor Gene

Rattus norvegicus

Also known as Cck2r; Cholrec

Gene ID: 25706 | Gene type: protein coding

About Cckbr

Primary_assembly 1: 159,771,733-159,814,881 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 12 phenotypes. Restricted expression toward (RPKM 39.4).

Summary

Cholecystokinin was one of the first gastrointestinal Peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a Cholecystokinin Receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008]

Cckbr Products(1)

mRNA	Protein	Name
NM_013165.3	NP_037297.2	gastrin/cholecystokinin type B receptor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables gastrin receptor activity	IMP IMP: Inferred from mutant phenotype	1528881	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17226751	RGD
involved in behavioral defense response	IMP IMP: Inferred from mutant phenotype	17498673	RGD
involved in estrous cycle	IDA IDA: Inferred from direct assay	17045752	RGD
involved in histamine secretion	IMP IMP: Inferred from mutant phenotype	17531331	RGD
involved in positive regulation of behavioral fear response	IMP IMP: Inferred from mutant phenotype	12373548	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17531331	RGD
involved in positive regulation of somatostatin secretion	IMP IMP: Inferred from mutant phenotype	19959964	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	19386755	RGD
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17904218	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	18088282	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	15161757	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckbr Protein Structure

7tm_GPCRs

0
100
200
300
400
452 a.a.

Protein Preferred Names

Protein Names

gastrin/cholecystokinin type B receptor

CCK-B receptor	CCK-BR
CCK2 receptor	CCK2-R
cholecystokinin-2 receptor

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0261	Pentagastrin	Activator	99.97%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19445	Gastrazole	Antagonist	/	Phase 3
HY-106840	L-365260	Antagonist	99.93%	Phase 2
HY-17617	Nastorazepide	Antagonist	99.95%	Phase 2
HY-106347	Itriglumide	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1097	Gastrin I, human		99.93%	Unkown
HY-129357	CCK-B Receptor Antagonist 2	Inhibitor	98.84%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-155205	GV150013X	Antagonist	/	Unkown
HY-111313	JNJ-26070109	Antagonist	/	Unkown
HY-119127	TP-680	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cckbr	NCBI	NCBI:887

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