Cntf - ciliary neurotrophic factor Gene

Rattus norvegicus

Gene ID: 25707 | Gene type: protein coding

About Cntf

Summary

Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Cntf Products(1)

mRNA	Protein	Name
NM_013166.2	NP_037298.2	ciliary neurotrophic factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ciliary neurotrophic factor receptor binding	IPI IPI: Inferred from physical interaction	1648265	RGD
enables cytokine activity	IDA IDA: Inferred from direct assay	8385113	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8385113	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte activation	IDA IDA: Inferred from direct assay	11771938	RGD
involved in axon regeneration	IDA IDA: Inferred from direct assay	16699509	RGD
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15342787	RGD
involved in membrane hyperpolarization	IDA IDA: Inferred from direct assay	15831538	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15574731	RGD
involved in nervous system development	IDA IDA: Inferred from direct assay	11932952	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15574731	RGD
involved in positive regulation of axon regeneration	IDA IDA: Inferred from direct assay	15574731	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	11771938	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15831538	RGD
involved in positive regulation of hormone secretion	IDA IDA: Inferred from direct assay	11771938	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15574731	RGD
involved in positive regulation of protein modification process	IDA IDA: Inferred from direct assay	14725620	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15574731	RGD
involved in regulation of resting membrane potential	IDA IDA: Inferred from direct assay	15831538	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19576889	RGD
involved in response to light intensity	IEP IEP: Inferred from expression pattern	21076359	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	12849744	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	14725620	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12849744	RGD
located in plasma membrane bounded cell projection cytoplasm	IDA IDA: Inferred from direct assay	12849744	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ciliary neurotrophic factor

ciliary neurotropic factor

Recombinant Cntf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7148	CNTF Protein, Rat	P20294 (A2-M200)	≥95%
HY-P7148A	CNTF Protein, Rat (His)	P20294 (A2-M200)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02923	CNTF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cntf	NCBI	NCBI:1270
Mus musculus	Cntf	NCBI	NCBI:12803

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