Ifng - interferon gamma Gene

Rattus norvegicus

Also known as If2f; IFNG2

Gene ID: 25712 | Gene type: protein coding

About Ifng

Summary

Predicted to enable cytokine activity. Involved in several processes, including negative regulation of cell population proliferation; positive regulation of NMDA glutamate receptor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; neuron projection; and perikaryon. Used to study several diseases, including Chagas disease; allergic conjunctivitis; allergic rhinitis; renal fibrosis; and ureteral obstruction. Biomarker of several diseases, including abdominal aortic aneurysm; autoimmune thyroiditis; pulpitis; tongue squamous cell carcinoma; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including ataxia telangiectasia; autoimmune disease (multiple); eczema herpeticum; Factor VIII deficiency; and leukemia (multiple). Orthologous to human IFNG (interferon gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ifng Products(1)

mRNA	Protein	Name
NM_138880.3	NP_620235.1	interferon gamma precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	20624457	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in microglial cell activation	IGI IGI: Inferred from genetic interaction	27094552	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11940252	RGD
involved in negative regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	20624457	RGD
involved in negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	1906384	RGD
involved in negative regulation of glomerular mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	1906384	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20624457	RGD
involved in neuroinflammatory response	IDA IDA: Inferred from direct assay	27235345	RGD
involved in positive regulation of MHC class II biosynthetic process	IEP IEP: Inferred from expression pattern	3127329	RGD
involved in positive regulation of NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	27094552	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12931271	RGD
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	2509328	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20624457	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	27235345	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19355840	RGD
involved in positive regulation of receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	20624457	RGD
involved in positive regulation of synaptic transmission, cholinergic	IDA IDA: Inferred from direct assay	1900518	RGD
involved in regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	10598324	RGD
involved in regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	15799032	RGD
involved in regulation of neuronal action potential	IDA IDA: Inferred from direct assay	7715823	RGD
involved in regulation of the force of heart contraction	IDA IDA: Inferred from direct assay	1900518	RGD
involved in response to tacrolimus	IEP IEP: Inferred from expression pattern	23867624	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19439114	RGD
involved in sensory perception of mechanical stimulus	IDA IDA: Inferred from direct assay	7715823	RGD
involved in type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	20624457	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2474612	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9396771	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon gamma

IFN-gamma

interferon 2f

Recombinant Ifng Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7095	IFN-gamma Protein, Rat	P01581 (G24-C156)	≥95%
HY-P7095A	IFN-gamma Protein, Rat (CHO)	P01581 (Q23-C156)	≥95%
HY-P73254	IFN-gamma Protein, Rat (HEK293, Fc)	P01581 (Q23-C156)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99292	Fontolizumab	Inhibitor	97.18%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149916	A2AR-antagonist-1	Antagonist	/	Unkown
HY-P10497	EBV BZLF1 (190-197)	Inhibitor	/	Unkown
HY-RS06587	IFNG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117786	Go 7874	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ifng	NCBI	NCBI:3458
Canis familiaris	Ifng	NCBI	NCBI:403801
Macaca fascicularis	Ifng	NCBI	NCBI:102128291
Mus musculus	Ifng	NCBI	NCBI:15978
Susscrofa domestica	Ifng	NCBI

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