SHPRH - SNF2 histone linker PHD RING helicase Gene

Homo sapiens

Also known as RAD5; bA545I5.2

Gene ID: 257218 | Gene type: protein coding

About SHPRH

Cytogenetic location: 6q24.3 Genomic coordinates (GRCh38): 6:145,857,838-145,964,358 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 30 paralogues. Ubiquitous expression in ovary (RPKM 1.7), thyroid (RPKM 1.5) and 25 other tissues.

Summary

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]

SHPRH Products(4)

mRNA	Protein	Name
NM_001042683.3	NP_001036148.2	E3 ubiquitin-protein ligase SHPRH isoform a
NM_001370327.1	NP_001357256.1	E3 ubiquitin-protein ligase SHPRH isoform a
NM_001370328.1	NP_001357257.1	E3 ubiquitin-protein ligase SHPRH isoform c
NM_173082.4	NP_775105.1	E3 ubiquitin-protein ligase SHPRH isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17108083	GOA
enables ubiquitin protein ligase activity	EXP EXP: Inferred from Experiment	17108083	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	25023518	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17108083	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	25023518	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	17108083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHPRH Protein Structure

SNF2_N

Linker_histone

zf-C3HC4_2

0
300
600
900
1200
1500
1683 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SHPRH

2610103K11Rik

SHPRH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SHPRH	Q149N8	BORCS6	Homo sapiens	Q96GS4	Y2H Prey Pooling	25416956
Intra	SHPRH	Q149N8	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	25416956
Intra	SHPRH	Q149N8	EDARADD	Homo sapiens	Q8WWZ3	Validated Y2H	25416956
Intra	SHPRH	Q149N8	EDARADD	Homo sapiens	Q8WWZ3	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12882	SHPRH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SHPRH	RGD	RGD:1310342
Felis catus	SHPRH	VGNC	VGNC:65131
Canis familiaris	SHPRH	VGNC	VGNC:49029
Macaca mulatta	SHPRH	VGNC	VGNC:77274
Bos taurus	SHPRH	VGNC	VGNC:50618
Mus musculus	SHPRH	MGD	MGI:1917581

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