Ppara - peroxisome proliferator activated receptor alpha Gene

Rattus norvegicus

Also known as PPAR

Gene ID: 25747 | Gene type: protein coding

About Ppara

Primary_assembly 7: 116,832,756-116,895,346 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 455 orthologues, 19 paralogues and is associated with 61 phenotypes. Biased expression in Liver (RPKM 134.1), Kidney (RPKM 127.) and 9 other tissues.

Summary

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara Products(1)

mRNA	Protein	Name
NM_013196.2	NP_037328.1	peroxisome proliferator-activated receptor alpha

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15661831	RGD
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	19103650	RGD
enables NFAT protein binding	IPI IPI: Inferred from physical interaction	22198280	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	28821620	RGD
enables nuclear receptor activity	IMP IMP: Inferred from mutant phenotype	12189208	RGD
enables phosphatase binding	IPI IPI: Inferred from physical interaction	8910358	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15051727	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	12189208	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	20132223	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12189208	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16280383	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	22464285	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to nicotine	IDA IDA: Inferred from direct assay	20801430	RGD
involved in cellular response to fructose stimulus	IEP IEP: Inferred from expression pattern	11934685	RGD
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	12600885	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15754086	RGD
involved in lipoprotein metabolic process	IMP IMP: Inferred from mutant phenotype	15537571	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	15967866	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	22198280	RGD
involved in nitric oxide metabolic process	IEP IEP: Inferred from expression pattern	31489946	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12189208	RGD
involved in regulation of lipid storage	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	15292030	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	33310031	RGD
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	16183630	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	33310031	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppara Protein Structure

NR_DBD_Ppar

NR_LBD_PPAR

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

peroxisome proliferator-activated receptor alpha

PPAR-alpha

nuclear receptor subfamily 1 group C member 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14728	Aleglitazar	Agonist	99.74%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121579	L-764406		/	Unkown
HY-RS10919	PPARA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10920	Ppara Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10921	Ppara Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppara	NCBI	NCBI:5465
Mus musculus	Ppara	NCBI	NCBI:19013

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