2. Gene
  3. SHC2 - SHC adaptor protein 2 Gene

SHC2 - SHC adaptor protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCK; SLI; SHCB

Gene ID: 25759 | Gene type: protein coding

About SHC2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:416,589-461,033 (from NCBI)

This gene has 6 transcripts (splice variants) and 10 orthologues. Ubiquitous expression in prostate (RPKM 10.2), gall bladder (RPKM 9.1) and 24 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC2 Products(2)

mRNA Protein Name
NM_001387056.1 NP_001373985.1 SHC-transforming protein 2 isoform 2
NM_012435.3 NP_036567.2 SHC-transforming protein 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC2 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (153 - 307)

SH2

SH2: SH2 domain (487 - 558)

  • 0
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  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 2

SH2 domain protein C2

Related Diseases

Diseases Alias
Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis
Vaginal Discharge
Seckel Syndrome 1

SCKL1

Nanocephalic Dwarfism

Microcephalic Primordial Dwarfism I

Seckel-Type Dwarfism

Bird-Headed Dwarfism

Sckl

Seckel Syndrome, Type 1

Seckel Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12857 SHC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SHC2 VGNC VGNC:65118
Mus musculus SHC2 MGD MGI:106180
Bos taurus SHC2 VGNC VGNC:55307
Rattus norvegicus SHC2 RGD RGD:1307137