DCAF13 - DDB1 and CUL4 associated factor 13 Gene

Homo sapiens

Also known as GM83; Sof1; WDSOF1; HSPC064

Gene ID: 25879 | Gene type: protein coding

About DCAF13

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,415,386-103,443,453 (from NCBI)

This gene has 10 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in testis (RPKM 16.5), kidney (RPKM 11.1) and 25 other tissues.

Summary

Enables Estrogen Receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCAF13 Products(1)

mRNA	Protein	Name
NM_015420.7	NP_056235.5	DDB1- and CUL4-associated factor 13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	28068668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28068668	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	30111536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in decidualization	IDA IDA: Inferred from direct assay	35932979	GOA
involved in epigenetic programming in the zygotic pronuclei	IDA IDA: Inferred from direct assay	30111536	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	30111536	GOA
involved in spindle assembly involved in female meiosis	IDA IDA: Inferred from direct assay	31492966	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul4-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16949367	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	30111536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF13 Protein Structure

WD40

Sof1

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

DDB1- and CUL4-associated factor 13

WD repeat and SOF domain-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03560	DCAF13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCAF13	MGD	MGI:2684929
Felis catus	DCAF13	VGNC	VGNC:81644
Rattus norvegicus	DCAF13	RGD	RGD:1308458
Bos taurus	DCAF13	VGNC	VGNC:53857
Canis familiaris	DCAF13	VGNC	VGNC:39791

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