2. Gene
  3. NELFB - negative elongation factor complex member B Gene

NELFB - negative elongation factor complex member B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as COBRA1; NELF-B

Gene ID: 25920 | Gene type: protein coding

About NELFB

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,255,327-137,273,542 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in testis (RPKM 16.5), fat (RPKM 16.5) and 25 other tissues.

Summary

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

NELFB Products(1)

mRNA Protein Name
NM_015456.5 NP_056271.3 negative elongation factor B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11739404 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
12612062 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NELF complex IDA
IDA: Inferred from direct assay
12612062 GOA
part of NELF complex IPI
IPI: Inferred from physical interaction
12612062 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12612062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELFB Protein Structure

COBRA1

COBRA1: Cofactor of BRCA1 (COBRA1) (106 - 579)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

negative elongation factor B

cofactor of BRCA1

NELFB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NELFB Q8WX92 MGST1 Homo sapiens P10620
Display Tech
20195357
Intra
NELFB Q8WX92 BRCA1 Homo sapiens P38398
Confocal
11739404
Intra
NELFB Q8WX92 DENR Homo sapiens O43583
Display Tech
20195357
Intra
NELFB Q8WX92 PIK3R1 Homo sapiens P27986
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09202 NELFB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NELFB VGNC VGNC:75243
Mus musculus NELFB MGD MGI:1931035
Bos taurus NELFB VGNC VGNC:54461
Canis familiaris NELFB VGNC VGNC:43737
Rattus norvegicus NELFB RGD RGD:1307832
Felis catus NELFB VGNC VGNC:63772