2. Gene
  3. NELFB - negative elongation factor complex member B Gene

NELFB - negative elongation factor complex member B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as COBRA1; NELF-B

Gene ID: 25920 | Gene type: protein coding

About NELFB

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,255,327-137,273,542 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in testis (RPKM 16.5), fat (RPKM 16.5) and 25 other tissues.

Summary

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

NELFB Products(1)

mRNA Protein Name
NM_015456.5 NP_056271.3 negative elongation factor B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11739404 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
12612062 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NELF complex IDA
IDA: Inferred from direct assay
12612062 GOA
part of NELF complex IPI
IPI: Inferred from physical interaction
12612062 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12612062 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELFB Protein Structure

COBRA1

COBRA1: Cofactor of BRCA1 (COBRA1) (106 - 579)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

negative elongation factor B

cofactor of BRCA1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09202 NELFB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NELFB VGNC VGNC:75243
Mus musculus NELFB MGD MGI:1931035
Bos taurus NELFB VGNC VGNC:54461
Canis familiaris NELFB VGNC VGNC:43737
Rattus norvegicus NELFB RGD RGD:1307832
Felis catus NELFB VGNC VGNC:63772