CNRIP1 - cannabinoid receptor interacting protein 1 Gene

Homo sapiens

Also known as CRIP1; CRIP-1; C2orf32

Gene ID: 25927 | Gene type: protein coding

About CNRIP1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:68,284,171-68,319,949 (from NCBI)

This gene has 4 transcripts (splice variants) and 264 orthologues. Broad expression in brain (RPKM 31.7), ovary (RPKM 14.7) and 21 other tissues.

Summary

This gene encodes a protein that interacts with the C-terminal tail of Cannabinoid Receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]

CNRIP1 Products(7)

mRNA	Protein	Name
NM_001111101.2	NP_001104571.1	CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1b
NM_001371604.1	NP_001358533.1	CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a
NM_001371605.1	NP_001358534.1	CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a
NM_001371606.1	NP_001358535.1	CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a
NM_001371607.1	NP_001358536.1	CB1 cannabinoid receptor-interacting protein 1 isoform 3
NM_001371608.1	NP_001358537.1	CB1 cannabinoid receptor-interacting protein 1 isoform 3
NM_015463.3	NP_056278.1	CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17895407	GOA
enables type 1 cannabinoid receptor binding	IPI IPI: Inferred from physical interaction	17895407	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	17895407	GOA
involved in regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	17895407	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17895407	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17895407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNRIP1 Protein Structure

CNRIP1

0
100
164 a.a.

Protein Preferred Names

Protein Names

CB1 cannabinoid receptor-interacting protein 1

cannabinoid receptor CB1-interacting protein 1

CNRIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNRIP1	Q96F85	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	CNRIP1	Q96F85	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	CNRIP1	Q96F85	PRTFDC1	Homo sapiens	Q9NRG1	Validated Y2H	32296183
Intra	CNRIP1	Q96F85	PRTFDC1	Homo sapiens	Q9NRG1	Y2H Array	32296183
Intra	CNRIP1	Q96F85	PRTFDC1	Homo sapiens	Q9NRG1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 58

DFNA58	Autosomal Dominant Nonsyndromic Deafness 58
Autosomal Dominant Deafness 58

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02920	CNRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CNRIP1	VGNC	VGNC:80072
Mus musculus	CNRIP1	MGD	MGI:1917505
Rattus norvegicus	CNRIP1	RGD	RGD:1308373
Bos taurus	CNRIP1	VGNC	VGNC:27531
Canis familiaris	CNRIP1	VGNC	VGNC:54520
Macaca mulatta	CNRIP1	VGNC	VGNC:106141

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