KRT23 - keratin 23 Gene

Homo sapiens

Also known as K23; CK23; HAIK1

Gene ID: 25984 | Gene type: protein coding

About KRT23

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,922,700-40,937,646 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 119 orthologues and 68 paralogues. Biased expression in placenta (RPKM 45.8), skin (RPKM 39.5) and 7 other tissues.

Summary

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

KRT23 Products(2)

mRNA	Protein	Name
NM_001282433.2	NP_001269362.1	keratin, type I cytoskeletal 23 isoform 2
NM_015515.5	NP_056330.3	keratin, type I cytoskeletal 23 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT23 Protein Structure

Filament

0
100
200
300
422 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 23

CK-23

Related Diseases

Diseases

Alias

Transitional Papilloma

Transitional Cell Papilloma

Transitional Cell Papilloma, Benign

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07447	KRT23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KRT23	VGNC	VGNC:74211
Canis familiaris	KRT23	VGNC	VGNC:42522
Rattus norvegicus	KRT23	RGD	RGD:1308838
Felis catus	KRT23	VGNC	VGNC:67987
Mus musculus	KRT23	MGD	MGI:2148866
Bos taurus	KRT23	VGNC	VGNC:30722

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