2. Gene
  3. RNF167 - ring finger protein 167 Gene

RNF167 - ring finger protein 167 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LP2254; RING105; 5730408C10Rik

Gene ID: 26001 | Gene type: protein coding

About RNF167

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,940,092-4,945,222 (from NCBI)

This gene has 16 transcripts (splice variants), 121 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues.

Summary

RNF167 is an E3 ubiquitin Ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

RNF167 Products(20)

mRNA Protein Name
NM_001320356.2 NP_001307285.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320357.2 NP_001307286.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320358.2 NP_001307287.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320359.2 NP_001307288.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320360.2 NP_001307289.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320361.2 NP_001307290.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320362.2 NP_001307291.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320363.2 NP_001307292.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320364.2 NP_001307293.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320365.2 NP_001307294.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370303.1 NP_001357232.1 E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370304.1 NP_001357233.1 E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370305.1 NP_001357234.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001370306.1 NP_001357235.1 E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370307.1 NP_001357236.1 E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370308.1 NP_001357237.1 E3 ubiquitin-protein ligase RNF167 isoform e
NM_001370311.1 NP_001357240.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370313.1 NP_001357242.1 E3 ubiquitin-protein ligase RNF167 isoform f precursor
NM_001375485.1 NP_001362414.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_015528.3 NP_056343.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16314844 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
23129617 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16314844 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to leucine starvation IDA
IDA: Inferred from direct assay
35114100 GOA
acts upstream of lysosome localization IDA
IDA: Inferred from direct assay
32409562 GOA
involved in lysosome localization IDA
IDA: Inferred from direct assay
27808481 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35114100 GOA
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
16314844 GOA
involved in organelle localization IMP
IMP: Inferred from mutant phenotype
24387786 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
33594058 GOA
involved in protein K29-linked ubiquitination IDA
IDA: Inferred from direct assay
33594058 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
35114100 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
16314844 GOA
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
23129617 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27808481 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16314844 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
32409562 GOA
is active in endolysosome membrane IDA
IDA: Inferred from direct assay
23129617 GOA
located in endosome IDA
IDA: Inferred from direct assay
24387786 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
27808481 GOA
is active in lysosome IDA
IDA: Inferred from direct assay
27808481 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF167 Protein Structure

PA

PA: PA domain (52 - 150)

zf-RING_2

zf-RING_2: Ring finger domain (228 - 272)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF167

RING-type E3 ubiquitin transferase RNF167

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 73

DEE73

Epileptic Encephalopathy, Early Infantile, 73

Eiee73

Developmental And Epileptic Encephalopathy, 73

Early Infantile Epileptic Encephalopathy 73

Rnf13-Related Severe Early-Onset Epileptic Encephalopathy

Rnf13-Related Severe Eoee
Lissencephaly 8

LIS8
Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12061 RNF167 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNF167 VGNC VGNC:76812
Mus musculus RNF167 MGD MGI:1917760
Rattus norvegicus RNF167 RGD RGD:1305972
Canis familiaris RNF167 VGNC VGNC:59031
Bos taurus RNF167 VGNC VGNC:57151