2. Gene
  3. GLCE - glucuronic acid epimerase Gene

GLCE - glucuronic acid epimerase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSEPI

Gene ID: 26035 | Gene type: protein coding

About GLCE

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,160,635-69,272,207 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues.

Summary

Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

GLCE Products(5)

mRNA Protein Name
NM_001324091.2 NP_001311020.1 D-glucuronyl C5-epimerase isoform 2
NM_001324092.2 NP_001311021.1 D-glucuronyl C5-epimerase isoform 3
NM_001324093.2 NP_001311022.1 D-glucuronyl C5-epimerase isoform 1
NM_001324094.2 NP_001311023.1 D-glucuronyl C5-epimerase isoform 1
NM_015554.3 NP_056369.1 D-glucuronyl C5-epimerase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
30872481 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IDA
IDA: Inferred from direct assay
15853773 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IMP
IMP: Inferred from mutant phenotype
20118238 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
30872481 GOA
Biological Process GO Annotation Evidence Reference Source
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
20118238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLCE Protein Structure

C5-epim_C

C5-epim_C: D-glucuronyl C5-epimerase C-terminus (416 - 607)

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  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

D-glucuronyl C5-epimerase

UDP-glucuronic acid epimerase

Related Diseases

Diseases Alias
Triosephosphate Isomerase Deficiency

TPID

Triose Phosphate-Isomerase Deficiency

Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Tpi Deficiency

Triose Phosphate Isomerase Deficiency

Deficiency Of Phosphotriose Isomerase

Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05467 GLCE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GLCE MGD MGI:2136405
Rattus norvegicus GLCE RGD RGD:1565253
Macaca mulatta GLCE VGNC VGNC:72959
Canis familiaris GLCE VGNC VGNC:41251
Bos taurus GLCE VGNC VGNC:29394
Felis catus GLCE VGNC VGNC:62573