POLDIP2 - DNA polymerase delta interacting protein 2 Gene

Homo sapiens

Also known as p38; POLD4; PDIP38

Gene ID: 26073 | Gene type: protein coding

About POLDIP2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,346,633-28,357,527 (from NCBI)

This gene has 2 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 32.9), adrenal (RPKM 29.4) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the DNA Polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

POLDIP2 Products(2)

mRNA	Protein	Name
NM_001290145.2	NP_001277074.1	polymerase delta-interacting protein 2 isoform 2
NM_015584.5	NP_056399.1	polymerase delta-interacting protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16428295	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in error-free translesion synthesis	IDA IDA: Inferred from direct assay	24191025	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	16428295	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	18063578	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16428295	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLDIP2 Protein Structure

DUF525

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

polymerase delta-interacting protein 2

38 kDa DNA polymerase delta interaction protein

POLDIP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLDIP2	Q9Y2S7	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	32296183
Intra	POLDIP2	Q9Y2S7	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	32296183
Intra	POLDIP2	Q9Y2S7	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	POLDIP2	Q9Y2S7	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	POLDIP2	Q9Y2S7	CHCHD2	Homo sapiens	Q9Y6H1	Validated Y2H	32296183
Intra	POLDIP2	Q9Y2S7	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	POLDIP2	Q9Y2S7	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

POLDIP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81935	POLDIP2 Antibody (YA1680)	WB, IP	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10823	POLDIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLDIP2	VGNC	VGNC:99322
Bos taurus	POLDIP2	VGNC	VGNC:33116
Rattus norvegicus	POLDIP2	RGD	RGD:1307022
Macaca mulatta	POLDIP2	VGNC	VGNC:76099
Canis familiaris	POLDIP2	VGNC	VGNC:44777
Mus musculus	POLDIP2	MGD	MGI:1915061

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