ARHGEF26 - Rho guanine nucleotide exchange factor 26 Gene

Homo sapiens

Also known as SGEF; CSGEF; HMFN1864

Gene ID: 26084 | Gene type: protein coding

About ARHGEF26

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:154,121,003-154,257,825 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 189 orthologues and 6 paralogues. Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues.

Summary

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

ARHGEF26 Products(3)

mRNA	Protein	Name
NM_001251962.2	NP_001238891.1	rho guanine nucleotide exchange factor 26 isoform 1
NM_001251963.2	NP_001238892.1	rho guanine nucleotide exchange factor 26 isoform 2
NM_015595.4	NP_056410.3	rho guanine nucleotide exchange factor 26 isoform 1

ARHGEF26 Protein Structure

RhoGEF

SH3_1

0
200
400
600
800
871 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 26

Rho guanine nucleotide exchange factor (GEF) 26

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00956	ARHGEF26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGEF26	RGD	RGD:1562559
Bos taurus	ARHGEF26	VGNC	VGNC:26113
Felis catus	ARHGEF26	VGNC	VGNC:59904
Canis familiaris	ARHGEF26	VGNC	VGNC:38082
Macaca mulatta	ARHGEF26	VGNC	VGNC:69897
Mus musculus	ARHGEF26	MGD	MGI:1918053

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