TANC2 - tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Gene

Homo sapiens

Also known as rols; ROLSA; IDDALDS

Gene ID: 26115 | Gene type: protein coding

About TANC2

Cytogenetic location: 17q23.2-q23.3 Genomic coordinates (GRCh38): 17:62,966,235-63,427,703 (from NCBI)

This gene has 11 transcripts (splice variants), 280 orthologues, 4 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues.

Summary

Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. [provided by Alliance of Genome Resources, Apr 2022]

TANC2 Products(3)

mRNA	Protein	Name
NM_001394998.1	NP_001381927.1	protein TANC2 isoform 2
NM_001411076.1	NP_001398005.1	protein TANC2 isoform 3
NM_025185.4	NP_079461.2	protein TANC2 isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	30021165	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TANC2 Protein Structure

Ank_2

Ank

Ank_2

Ank

TPR_11

0
400
800
1200
1600
1990 a.a.

Protein Preferred Names

Protein Names

protein TANC2

putative ankyrin-repeat containing protein

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Autistic Features And Language Delay, With Or Without Seizures

IDDALDS

Intellectual Developmental Disorder With Autistic Features And Language Delay Without Seizures

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14195	TANC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TANC2	VGNC	VGNC:47099
Felis catus	TANC2	VGNC	VGNC:65949
Rattus norvegicus	TANC2	RGD	RGD:1309285
Bos taurus	TANC2	VGNC	VGNC:35592
Mus musculus	TANC2	MGD	MGI:2444121
Macaca mulatta	TANC2	VGNC	VGNC:99281

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