1. Gene
  2. TTLL3 - tubulin tyrosine ligase like 3 Gene

TTLL3 - tubulin tyrosine ligase like 3 Gene

Homo sapiens

Also known as HOTTL

Gene ID: 26140 | Gene type: protein coding

About TTLL3

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,809,727-9,836,365 (from NCBI)

This gene has 35 transcripts (splice variants), 240 orthologues and 12 paralogues. Ubiquitous expression in ovary (RPKM 13.9), testis (RPKM 13.9) and 24 other tissues.

Summary

Enables protein-glycine Ligase activity. Predicted to be involved in axoneme assembly and flagellated sperm motility. Predicted to be located in axoneme; microtubule cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]

TTLL3 Products(24)

mRNA Protein Name
NM_001025930.5 NP_001021100.3 tubulin monoglycylase TTLL3 isoform 1
NM_001366051.2 NP_001352980.1 tubulin monoglycylase TTLL3 isoform 2
NM_001387446.1 NP_001374375.1 tubulin monoglycylase TTLL3 isoform 3
NM_001387447.1 NP_001374376.1 tubulin monoglycylase TTLL3 isoform 4
NM_001387448.1 NP_001374377.1 tubulin monoglycylase TTLL3 isoform 5
NM_001387449.1 NP_001374378.1 tubulin monoglycylase TTLL3 isoform 6
NM_001387450.1 NP_001374379.1 tubulin monoglycylase TTLL3 isoform 7
NM_001387451.1 NP_001374380.1 tubulin monoglycylase TTLL3 isoform 8
NM_001387452.1 NP_001374381.1 tubulin monoglycylase TTLL3 isoform 9
NM_001387453.1 NP_001374382.1 tubulin monoglycylase TTLL3 isoform 10
NM_001387454.1 NP_001374383.1 tubulin monoglycylase TTLL3 isoform 11
NM_001387455.1 NP_001374384.1 tubulin monoglycylase TTLL3 isoform 11
NM_001387456.1 NP_001374385.1 tubulin monoglycylase TTLL3 isoform 11
NM_001387457.1 NP_001374386.1 tubulin monoglycylase TTLL3 isoform 12
NM_001387458.1 NP_001374387.1 tubulin monoglycylase TTLL3 isoform 13
NM_001387459.1 NP_001374388.1 tubulin monoglycylase TTLL3 isoform 14
NM_001387460.1 NP_001374389.1 tubulin monoglycylase TTLL3 isoform 14
NM_001387461.1 NP_001374390.1 tubulin monoglycylase TTLL3 isoform 15
NM_001387462.1 NP_001374391.1 tubulin monoglycylase TTLL3 isoform 16
NM_001387463.1 NP_001374392.1 tubulin monoglycylase TTLL3 isoform 17
NM_001387464.1 NP_001374393.1 tubulin monoglycylase TTLL3 isoform 18
NM_001387465.1 NP_001374394.1 tubulin monoglycylase TTLL3 isoform 18
NM_001387466.1 NP_001374395.1 tubulin monoglycylase TTLL3 isoform 19
NM_001387467.1 NP_001374396.1 tubulin monoglycylase TTLL3 isoform 20
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein-glycine ligase activity IDA
IDA: Inferred from direct assay
19524510 GOA
Biological Process GO Annotation Evidence Reference Source
NOT involved in protein polyglycylation IDA
IDA: Inferred from direct assay
19524510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL3 Protein Structure

TTL

TTL: Tubulin-tyrosine ligase family (359 - 644)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
Protein Preferred Names Protein Names

tubulin monoglycylase TTLL3

tubulin tyrosine ligase-like family, member 3

Related Diseases

Diseases Alias
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus TTLL3 MGD MGI:2141418
Rattus norvegicus TTLL3 RGD RGD:1311255