MTG2 - mitochondrial ribosome associated GTPase 2 Gene

Homo sapiens

Also known as ObgH1; GTPBP5; dJ1005F21.2

Gene ID: 26164 | Gene type: protein coding

About MTG2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,183,028-62,203,568 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 3.6), skin (RPKM 3.3) and 25 other tissues.

Summary

Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]

MTG2 Products(3)

mRNA	Protein	Name
NM_001384347.1	NP_001371276.1	mitochondrial ribosome-associated GTPase 2 isoform 1
NM_001384348.1	NP_001371277.1	mitochondrial ribosome-associated GTPase 2 isoform 3
NM_015666.4	NP_056481.1	mitochondrial ribosome-associated GTPase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	23396448	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of mitochondrial translation	IMP IMP: Inferred from mutant phenotype	23396448	GOA
involved in regulation of respiratory system process	IMP IMP: Inferred from mutant phenotype	23396448	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	23396448	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	23396448	GOA
located in mitochondrial ribosome	IDA IDA: Inferred from direct assay	23396448	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTG2 Protein Structure

GTP1_OBG

MMR_HSR1

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

mitochondrial ribosome-associated GTPase 2

GTP binding protein 5 (putative)

Related Diseases

Diseases

Alias

Endocervicitis

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08773	MTG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MTG2	MGD	MGI:106565
Bos taurus	MTG2	VGNC	VGNC:31729
Rattus norvegicus	MTG2	RGD	RGD:1359243
Canis familiaris	MTG2	VGNC	VGNC:43471
Macaca mulatta	MTG2	VGNC	VGNC:74972
Felis catus	MTG2	VGNC	VGNC:63649

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