2. Gene
  3. TIAM2 - TIAM Rac1 associated GEF 2 Gene

TIAM2 - TIAM Rac1 associated GEF 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as STEF; TIAM-2

Gene ID: 26230 | Gene type: protein coding

About TIAM2

Cytogenetic location: 6q25.2-q25.3 Genomic coordinates (GRCh38): 6:154,995,315-155,257,723 (from NCBI)

This gene has 20 transcripts (splice variants), 273 orthologues and 22 paralogues. Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues.

Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

TIAM2 Products(4)

mRNA Protein Name
NM_001010927.3 NP_001010927.2 rho guanine nucleotide exchange factor TIAM2 isoform b
NM_001384546.1 NP_001371475.1 rho guanine nucleotide exchange factor TIAM2 isoform a
NM_001384547.1 NP_001371476.1 rho guanine nucleotide exchange factor TIAM2 isoform a
NM_012454.4 NP_036586.3 rho guanine nucleotide exchange factor TIAM2 isoform a

TIAM2 Protein Structure

PH

PH: PH domain (508 - 619)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (892 - 964)

RhoGEF

RhoGEF: RhoGEF domain (1103 - 1292)

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  • 1701 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor TIAM2

SIF and TIAM1-like exchange factor

Related Diseases

Diseases Alias
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14516 TIAM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TIAM2 RGD RGD:2324148
Bos taurus TIAM2 VGNC VGNC:96546
Felis catus TIAM2 VGNC VGNC:96551
Canis familiaris TIAM2 VGNC VGNC:81888
Macaca mulatta TIAM2 VGNC VGNC:81887
Mus musculus TIAM2 MGD MGI:1344338