CLEC4E - C-type lectin domain family 4 member E Gene

Homo sapiens

Also known as MINCLE; CLECSF9

Gene ID: 26253 | Gene type: protein coding

About CLEC4E

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,533,305-8,540,905 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 14 paralogues. Biased expression in appendix (RPKM 10.3), spleen (RPKM 8.6) and 11 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4E Products(2)

mRNA	Protein	Name
NM_001410969.1	NP_001397898.1	C-type lectin domain family 4 member E isoform 2
NM_014358.4	NP_055173.1	C-type lectin domain family 4 member E isoform 1

CLEC4E Protein Structure

Lectin_C

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 4 member E

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9

Recombinant CLEC4E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70118	CLEC4E Protein, Human (HEK293, His)	Q9ULY5 (R41-L219)	≥95%

Related Diseases

Diseases

Alias

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Candidal Paronychia

Candidiasis Of Skin	Candidiasis Of Skin And Nails
Candidal Perionyxis

Fungal Infectious Disease

Mycoses

Mycosis

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Primary Systemic Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Invasive Aspergillosis

Aspergillosis Invasive

Common Wart

Verruca Vulgaris	Viral Warts Nos
Filiform Warts	Digitate Warts

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

Tinea Pedis

Athlete'S Foot	Dermatophytosis Of Foot
Ringworm Of Foot	Moccasin Foot

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02794	CLEC4E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLEC4E	MGD	MGI:1861232
Bos taurus	CLEC4E	VGNC	VGNC:27432
Macaca mulatta	CLEC4E	VGNC	VGNC:99916
Rattus norvegicus	CLEC4E	RGD	RGD:1359298
Others	CLEC4E	NCBI

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