2. Gene
  3. CABYR - calcium binding tyrosine phosphorylation regulated Gene

CABYR - calcium binding tyrosine phosphorylation regulated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CT88; FSP2; CBP86; FSP-2; CABYRa; CABYRc; CABYRe; CABYRc/d

Gene ID: 26256 | Gene type: protein coding

About CABYR

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,139,062-24,161,600 (from NCBI)

This gene has 19 transcripts (splice variants) and 124 orthologues. Restricted expression toward testis (RPKM 117.5).

Summary

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

CABYR Products(7)

mRNA Protein Name
NM_001308231.2 NP_001295160.1 calcium-binding tyrosine phosphorylation-regulated protein isoform f
NM_012189.4 NP_036321.2 calcium-binding tyrosine phosphorylation-regulated protein isoform a
NM_138643.3 NP_619584.1 calcium-binding tyrosine phosphorylation-regulated protein isoform d
NM_138644.3 NP_619585.1 calcium-binding tyrosine phosphorylation-regulated protein isoform c
NM_153768.3 NP_722452.1 calcium-binding tyrosine phosphorylation-regulated protein isoform b
NM_153769.3 NP_722453.1 calcium-binding tyrosine phosphorylation-regulated protein isoform c
NM_153770.3 NP_722454.1 calcium-binding tyrosine phosphorylation-regulated protein isoform e
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
11820818 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21274509 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15752768 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11820818 GOA
located in motile cilium IDA
IDA: Inferred from direct assay
18421703 GOA
located in sperm fibrous sheath IDA
IDA: Inferred from direct assay
11820818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABYR Protein Structure

RIIa

RIIa: Regulatory subunit of type II PKA R-subunit (12 - 48)

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  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

calcium-binding tyrosine phosphorylation-regulated protein

calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01788 CABYR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CABYR VGNC VGNC:26669
Macaca mulatta CABYR VGNC VGNC:70560
Rattus norvegicus CABYR RGD RGD:1585413
Mus musculus CABYR MGD MGI:1918382
Canis familiaris CABYR VGNC VGNC:38629
Felis catus CABYR VGNC VGNC:80428