2. Gene
  3. FBXO25 - F-box protein 25 Gene

FBXO25 - F-box protein 25 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBX25

Gene ID: 26260 | Gene type: protein coding

About FBXO25

Cytogenetic location: 8p23.3 Genomic coordinates (GRCh38): 8:406,958-477,967 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 1 paralogue. Broad expression in testis (RPKM 13.0), thyroid (RPKM 5.9) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

FBXO25 Products(3)

mRNA Protein Name
NM_012173.4 NP_036305.2 F-box only protein 25 isoform 3
NM_183420.2 NP_904356.1 F-box only protein 25 isoform 2
NM_183421.2 NP_904357.1 F-box only protein 25 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20473970 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16278047 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16278047 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box only protein 25

F-box protein Fbx25

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04800 FBXO25 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FBXO25 VGNC VGNC:72496
Felis catus FBXO25 VGNC VGNC:62183
Bos taurus FBXO25 VGNC VGNC:28900
Mus musculus FBXO25 MGD MGI:1914072
Canis familiaris FBXO25 VGNC VGNC:40768
Rattus norvegicus FBXO25 RGD RGD:1359105