PLA2G2D - phospholipase A2 group IID Gene

Homo sapiens

Also known as SPLASH; sPLA2S; PLA2IID; sPLA2-IID

Gene ID: 26279 | Gene type: protein coding

About PLA2G2D

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,111,939-20,119,536 (from NCBI)

This gene has 2 transcripts (splice variants), 118 orthologues and 8 paralogues. Biased expression in lymph node (RPKM 63.3), appendix (RPKM 10.7) and 2 other tissues.

Summary

This gene encodes a secreted member of the Phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

PLA2G2D Products(2)

mRNA	Protein	Name
NM_001271814.2	NP_001258743.1	group IID secretory phospholipase A2 isoform 2 precursor
NM_012400.4	NP_036532.1	group IID secretory phospholipase A2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	10681567	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	10681567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G2D Protein Structure

Phospholip_A2_1

0
100
145 a.a.

Protein Preferred Names

Protein Names

group IID secretory phospholipase A2

GIID sPLA2

Recombinant PLA2G2D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71653	PLA2G2D Protein, Human (His-SUMO)	Q9UNK4 (22I-145C)	≥95%

Related Diseases

Diseases

Alias

Gas Gangrene

Myonecrosis	Gas Bacillus Infection
Gas Gangrene Due To Clostridia	Clostridial Myonecrosis
Clostridial Cellulitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10622	PLA2G2D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLA2G2D	RGD	RGD:1309862
Canis familiaris	PLA2G2D	VGNC	VGNC:44623
Felis catus	PLA2G2D	VGNC	VGNC:107601
Macaca mulatta	PLA2G2D	VGNC	VGNC:100038
Mus musculus	PLA2G2D	MGD	MGI:1341796
Others	PLA2G2D	NCBI

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