IL1RAPL2 - interleukin 1 receptor accessory protein like 2 Gene

Homo sapiens

Also known as IL1R9; IL-1R9; TIGIRR-1; IL1RAPL-2

Gene ID: 26280 | Gene type: protein coding

About IL1RAPL2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:104,566,199-105,767,829 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008]

IL1RAPL2 Products(1)

mRNA	Protein	Name
NM_017416.2	NP_059112.1	X-linked interleukin-1 receptor accessory protein-like 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	21926414	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	21926414	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21926414	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21926414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RAPL2 Protein Structure

Ig_2

Ig_3

TIR

0
200
400
600
686 a.a.

Protein Preferred Names

Protein Names

X-linked interleukin-1 receptor accessory protein-like 2

IL-1 receptor accessory protein-like 2

Recombinant IL1RAPL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73151	IL-1R9/IL1RAPL2 Protein, Human (HEK293, Fc)	Q9NP60 (T17-K354)	≥95%
HY-P73895	IL-1R9/IL1RAPL2 Protein, Human (HEK293, His)	Q9NP60 (T17-E356)	≥95%

Related Diseases

Diseases

Alias

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Muckle-Wells Syndrome

MWS	Urticaria-Deafness-Amyloidosis Syndrome
Uda Syndrome	Neutrophilic Urticaria
Urticaria, Deafness And Amyloidosis	Cryopyrin-Associated Periodic Syndrome 2
Caps2	Muckle Wells Syndrome
Urticaria-Deafness-Amyloidosis	Cryopyrin-Associated Periodic Syndromes

Adult-Onset Still'S Disease

Adult-Onset Still Disease	Adult Onset Still'S Disease
Adult Still'S Disease	Still'S Disease Adult Onset
Aosd	Wissler-Fanconi Syndrome
Stills Disease Adult-Onset	Still'S Disease, Adult-Onset
Wissler'S Syndrome

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Schnitzler Syndrome

Chronic Urticaria With Gammopathy	Chronic Urticaria With Macroglobulinemia
Chronic Urticaria With Gammapathy

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Blau Syndrome

Arthrocutaneouveal Granulomatosis	Jabs Syndrome
BLAUS	Sarcoidosis, Early-Onset
Acug	Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial
Eos	Granulomatosis, Familial Juvenile Systemic
Granulomatosis, Familial, Blau Type	Familial Juvenile Systemic Granulomatosis
Early Onset Sarcoidosis	Synovitis Granulomatous With Uveitis And Cranial Neuropathies
Early-Onset Sarcoidosis	Familial Granulomatosis, Blau Type
Pediatric Granulomatous Arthritis	Familial Granulomatosis Blau Type
Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis	Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies

Dengue Shock Syndrome

Dss

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Dysentery

Infectious Diarrhea

Protein-Energy Malnutrition

PEM	Protein Energy Malnutrition

Scleritis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Proteasome-Associated Autoinflammatory Syndrome 1

Jmp Syndrome	Nakajo-Nishimura Syndrome
Nkjo	Autoinflammation, Lipodystrophy, And Dermatosis Syndrome
Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms	Nakajo Syndrome
PRAAS1	Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome
Candle	Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy
Aldd	Inflammation
Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy	Nakajo Nishimura Syndrome
Amyotrophy Fat Tissue Anomaly	Japanese Autoinflammatory Syndrome With Lipodystrophy
Jasl	Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy
Nns	Nodular Erythema With Digital Changes
Secondary Hypertrophic Osteoperiostosis With Pernio

Indolent Plasma Cell Myeloma

Indolent Myeloma

Indolent Multiple Myeloma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Glycerol Kinase Deficiency

Hyperglycerolemia	GKD
Gk Deficiency	Gk1 Deficiency
Deficiency Of Glycerol Kinase	Isolated Glycerol Kinase Deficiency
Glycerol Kinase Deficiency, Adult Form	Glycerol Kinase Deficiency, Juvenile Form
Deficiency, Glycerol Kinase

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis	Juvenile Chronic Polyarthritis
Monarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Arthritis
Still'S Disease	Systemic Juvenile Rheumatoid Arthritis
Juvenile Chronic Arthritis	Acute Juvenile Rheumatoid Arthritis
Pauciarticular Onset Juvenile Chronic Arthritis	Arthritis, Juvenile Rheumatoid
Jia	Jra
Juvenile Ra	Arthritis Juvenile Rheumatoid
Stills Disease	Juvenile Arthritis
Acute Polyarticular Juvenile Rheumatoid Arthritis	Pauciarticular Juvenile Rheumatoid Arthritis
Rheumatoid Arthritis, Systemic Juvenile

Psoriasis

Spondylarthropathy

Spondylarthropathies

Temporomandibular Joint Anomaly

Temporomandibular Joint Dysfunction	Temporomandibular Joint Disorder
Temporomandibular Joint Disease	Temporomandibular Jaw Disorder
Tmj - [Temporomandibular Joint] Disorder	Temporomandibular Developmental Disorder Of Jaw
Temporomandibular Dysfunction	Temporomandibular Joint Syndrome
Temporomandibular Joint-Pain-Dysfunction Syndrome	Mandibular Dysfunction Nos
Tmj - [Temporomandibular Joint Disorder] Syndrome	Tmjpds - [Temporomandibular Joint Pain Dysfunction Syndrome]
Tmj - [Temporomandibular Joint] Dysfunction

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06724	IL1RAPL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL1RAPL2	MGD	MGI:1913106
Macaca mulatta	IL1RAPL2	VGNC	VGNC:73720
Rattus norvegicus	IL1RAPL2	RGD	RGD:1561761
Others	IL1RAPL2	NCBI

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