IL-1R9/IL1RAPL2 Protein, Human (HEK293, His)

Interleukin-1 (IL-1) is a receptor that mediates gene expression for the synthesis of proteins associated with inflammation. IL1RAPL2 is associated with non-syndromic X-linked mental retardation. IL1RAPL2 is specifically expressed in the nervous system and is a candidate gene for central nervous system diseases. IL-1R9/IL1RAPL2 Protein, Human (HEK293, His) is the recombinant human-derived IL-1R9/IL1RAPL2 protein, expressed by HEK293, with C-His labeled tag. The total length of IL-1R9/IL1RAPL2 Protein, Human (HEK293, His) is 340 a.a., with molecular weight of ~48-55 kDa.

Interleukin-1 (IL-1) is a receptor that mediates gene expression for the synthesis of proteins associated with inflammation. The IL1RAPL2 protein is a member of the interleukin-1 receptor family and is similar to interleukin-1 receptor helper protein-like 1 (IL1RAPL1). IL-1 plays a key role in the pathogenesis of polymyositis and dermatomyositis. IL1RAPL2 is associated with non-syndromic X-linked mental retardation. IL1RAPL2 is specifically expressed in the nervous system and is a candidate gene for central nervous system diseases^[1][2][3][4].

Immobilized Human IL-1R9 at 0.5 μg/mL (100 μL/well) can bind Human PTPRD. The ED₅₀ for this effect is 136.4 ng/mL.

Human

HEK293

C-His

Q9NP60 (T17-E356)

26280  [NCBI]

Approximately 48-55 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.