GBX1 - gastrulation brain homeobox 1 Gene

Homo sapiens

Also known as Huh-17

Gene ID: 2636 | Gene type: protein coding

About GBX1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,148,009-151,167,694 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 2.3).

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of nervous system development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within adult walking behavior; neuron differentiation; and proprioception. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

GBX1 Products(1)

mRNA	Protein	Name
NM_001098834.3	NP_001092304.1	homeobox protein GBX-1

GBX1 Protein Structure

Homeobox

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

homeobox protein GBX-1

gastrulation and brain-specific homeobox protein 1

Related Diseases

Diseases

Alias

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05314	GBX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GBX1	VGNC	VGNC:108408
Bos taurus	GBX1	VGNC	VGNC:53645
Mus musculus	GBX1	MGD	MGI:95667
Felis catus	GBX1	VGNC	VGNC:62484
Rattus norvegicus	GBX1	RGD	RGD:621864

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