Esrrb - estrogen related receptor, beta Gene

Mus musculus

Also known as Err2; Errb; Nr3b2; Estrrb

Gene ID: 26380 | Gene type: protein coding

About Esrrb

Chromosome 12: 86,407,891-86,568,402 forward strand.GRCm39:CM001005.3

This gene has 6 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 15 phenotypes. Biased expression in kidney adult (RPKM 6.2), heart adult (RPKM 4.9) and 12 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Esrrb Products(2)

mRNA	Protein	Name
NM_001159500.1	NP_001152972.1	steroid hormone receptor ERR2 isoform 2
NM_011934.4	NP_036064.3	steroid hormone receptor ERR2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18957414	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18662995	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	27723719	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18662995	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	27723719	MGI
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	23019124	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18662995	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23508100	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18509053	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23169531	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell dedifferentiation	IDA IDA: Inferred from direct assay	23040477	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	9285590	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9285590	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	17765677	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18957414	MGI
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	26206133	MGI
involved in photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	20534447	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20534447	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23019124	MGI
involved in positive regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	24481529	MGI
involved in positive regulation of stem cell population maintenance	IDA IDA: Inferred from direct assay	23040477	MGI
involved in positive regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	23019124	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22977234	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18662995	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27723719	MGI
involved in regulation of stem cell division	IDA IDA: Inferred from direct assay	23040477	MGI
involved in regulation of stem cell division	IMP IMP: Inferred from mutant phenotype	23019124	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16518401	MGI
involved in stem cell division	IMP IMP: Inferred from mutant phenotype	23040478	MGI
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	18957414	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	23169531	MGI
acts upstream of or within trophectodermal cell proliferation	IMP IMP: Inferred from mutant phenotype	9285590	MGI
acts upstream of or within trophectodermal cellular morphogenesis	IMP IMP: Inferred from mutant phenotype	9285590	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in condensed chromosome	IMP IMP: Inferred from mutant phenotype	27723719	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18472334	MGI
part of integrator complex	IDA IDA: Inferred from direct assay	26206133	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18472334	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrrb Protein Structure

NR_DBD_ERR

NR_LBD_ERR

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

steroid hormone receptor ERR2

ERR-beta	estrogen receptor related 2
estrogen receptor-like 2	nuclear receptor subfamily 3 group B member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04540	ESRRB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04541	Esrrb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04542	ESRRB Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esrrb	NCBI	NCBI:2103

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