Esrrg - estrogen-related receptor gamma Gene

Mus musculus

Also known as ERR3; Errg; NR3B3; mKIAA0832

Gene ID: 26381 | Gene type: protein coding

About Esrrg

Chromosome 1: 187,340,988-187,947,082 forward strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 136 orthologues, 8 paralogues and is associated with 23 phenotypes. Biased expression in cerebellum adult (RPKM 6.9), kidney adult (RPKM 4.9) and 12 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Esrrg Products(5)

mRNA	Protein	Name
NM_011935.3	NP_036065.1	estrogen-related receptor gamma isoform1
NM_001357536.1	NP_001344465.1	estrogen-related receptor gamma isoform 3
NM_001357534.1	NP_001344463.1	estrogen-related receptor gamma isoform 2
NM_001243792.1	NP_001230721.1	estrogen-related receptor gamma isoform 2
NM_001357535.1	NP_001344464.1	estrogen-related receptor gamma isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10428842	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15149736	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15149736	MGI
enables estrogen response element binding	IDA IDA: Inferred from direct assay	10428842	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10428842	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12715898	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	17229846	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10428842	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15149736	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esrrg Protein Structure

NR_DBD_ERR

NR_LBD_ERR

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

estrogen-related receptor gamma

estrogen receptor-related protein 3	estrogen-related receptor 3
nuclear receptor subfamily 3 group B member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04543	ESRRG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04544	Esrrg Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04545	Esrrg Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Esrrg	NCBI	NCBI:2104

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