Map2k2 - mitogen-activated protein kinase kinase 2 Gene

Mus musculus

Also known as MK2; MEK2; Prkmk2

Gene ID: 26396 | Gene type: protein coding

About Map2k2

Chromosome 10: 80,941,749-80,969,809 forward strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 8 phenotypes. Ubiquitous expression in duodenum adult (RPKM 23.), adrenal adult (RPKM 218.2) and 28 other tissues.

Summary

Enables molecular adaptor activity. Involved in positive regulation of cell motility. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and regulation of neuron projection development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products(3)

mRNA	Protein	Name
NM_001347144.1	NP_001334073.1	dual specificity mitogen-activated protein kinase kinase 2 isoform 2
NM_023138.5	NP_075627.2	dual specificity mitogen-activated protein kinase kinase 2 isoform 1
NM_001358539.1	NP_001345468.1	dual specificity mitogen-activated protein kinase kinase 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	8297798	MGI
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	20179103	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17380122	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	24493648	MGI
acts upstream of or within ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	25100655	MGI
involved in MAPK cascade	IGI IGI: Inferred from genetic interaction	21220101	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within epithelial cell proliferation involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	25100655	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	18952847	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21699731	MGI
acts upstream of or within lung morphogenesis	IGI IGI: Inferred from genetic interaction	25100655	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within positive regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	24733831	MGI
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	20179103	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	19047410	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	24733831	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	18952847	MGI
acts upstream of or within trachea formation	IGI IGI: Inferred from genetic interaction	25100655	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23920377	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k2 Protein Structure

PKc_MEK

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 2

ERK activator kinase 2	MAP kinase kinase 2
MAP kinase/Erk kinase	MAPK/ERK kinase 2
MAPKK 2	MEK 2
protein kinase, mitogen activated, kinase 2, p45

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k2	NCBI	NCBI:5605

Name
Email *

	Sorry, but the email address you supplied was invalid.