Mapk14 - mitogen-activated protein kinase 14 Gene

Mus musculus

Also known as p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha

Gene ID: 26416 | Gene type: protein coding

About Mapk14

Chromosome 17: 28,910,303-28,967,380 forward strand.GRCm39:CM001010.3

This gene has 10 transcripts (splice variants), 295 orthologues, 19 paralogues and is associated with 49 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues.

Summary

Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of cell differentiation. Located in several cellular components, including cytosol; mitochondrion; and spindle pole. Is active in glutamatergic synapse. Is expressed in several structures, including brain; early conceptus; epidermis; genitourinary system; and lung. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products(5)

mRNA	Protein	Name
NM_011951.3	NP_036081.1	mitogen-activated protein kinase 14 isoform 1
NM_001168508.1	NP_001161980.1	mitogen-activated protein kinase 14 isoform 2
NM_001168513.1	NP_001161985.1	mitogen-activated protein kinase 14 isoform 3
NM_001168514.1	NP_001161986.1	mitogen-activated protein kinase 14 isoform 3
NM_001357724.1	NP_001344653.1	mitogen-activated protein kinase 14 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	7914033	MGI
enables MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20551513	MGI
enables NFAT protein binding	IPI IPI: Inferred from physical interaction	15304486	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	12808090	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10415025	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10943842	MGI
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	16364914	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18347059	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of D-glucose import	IMP IMP: Inferred from mutant phenotype	19403598	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12937170	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	20212154	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	20551513	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	10973481	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	20551513	MGI
involved in cartilage condensation	IMP IMP: Inferred from mutant phenotype	17202865	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	17686994	MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IGI IGI: Inferred from genetic interaction	18363966	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: Inferred from direct assay	17644814	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17202865	MGI
acts upstream of or within fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	12802337	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12802337	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	7914033	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	12872135	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17202865	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20551513	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15304486	MGI
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	22847234	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18347059	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15304486	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	21768366	MGI
acts upstream of or within positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	19403598	MGI
acts upstream of or within positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23977283	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	21768366	MGI
acts upstream of or within positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10943842	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22897442	MGI
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	22847234	MGI
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	22847234	MGI
involved in positive regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	22847234	MGI
acts upstream of or within positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	16954198	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10943842	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15767678	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15937334	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20212154	MGI
acts upstream of or within regulation of ossification	IDA IDA: Inferred from direct assay	20053668	MGI
involved in regulation of synaptic membrane adhesion	EXP EXP: Inferred from Experiment	17988630	MGI
involved in regulation of synaptic membrane adhesion	IDA IDA: Inferred from direct assay	17988630	MGI
involved in regulation of synaptic membrane adhesion	IEP IEP: Inferred from expression pattern	17988630	MGI
involved in regulation of synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	17988630	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22847234	MGI
involved in response to dietary excess	IMP IMP: Inferred from mutant phenotype	19948881	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	19948881	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to muramyl dipeptide	IDA IDA: Inferred from direct assay	15692051	MGI
acts upstream of or within response to muscle stretch	IMP IMP: Inferred from mutant phenotype	19403598	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	15890335	MGI
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	17644814	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	20160094	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10943842	MGI
acts upstream of or within positive effect tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19948881	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10601328	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	21976273	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11884367	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17988630	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17988630	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17988630	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17988630	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11884367	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10601328	MGI
located in spindle pole	IDA IDA: Inferred from direct assay	15509711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk14 Protein Structure

STKc_p38alpha

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 14

MAP kinase 14	MAP kinase p38 alpha
MAPK 14	mitogen-activated protein kinase p38 alpha
p38 MAP kinase alpha	p38 MAPK

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10401	VX-702	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148063	DB0614		98.80%	Unkown
HY-18874	p38-α MAPK-IN-1	Inhibitor	99.89%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS08108	Mapk14 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08107	MAPK14 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08109	Mapk14 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk14	NCBI	NCBI:1432

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