Mapk9 - mitogen-activated protein kinase 9 Gene

Mus musculus

Also known as JNK2; Prkm9; p54aSAPK

Gene ID: 26420 | Gene type: protein coding

About Mapk9

Chromosome 11: 49,737,578-49,777,248 forward strand.GRCm39:CM001004.3

This gene has 10 transcripts (splice variants), 221 orthologues, 19 paralogues and is associated with 20 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 32.4), cortex adult (RPKM 26.9) and 28 other tissues.

Summary

Enables protein serine/threonine/tyrosine kinase activity. Involved in peptidyl-serine phosphorylation; positive regulation of cellular protein metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is expressed in several structures, including brain; extraembryonic component; future brain; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mapk9 Products(4)

mRNA	Protein	Name
NM_016961.3	NP_058657.1	mitogen-activated protein kinase 9 isoform beta1
NM_001163671.1	NP_001157143.1	mitogen-activated protein kinase 9 isoform beta2
NM_207692.2	NP_997575.2	mitogen-activated protein kinase 9 isoform alpha2
NM_001163672.1	NP_001157144.1	mitogen-activated protein kinase 9 isoform alpha1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables JUN kinase activity	IDA IDA: Inferred from direct assay	27830702	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10471813	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	24889144	MGI
enables protein serine/threonine/tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	29153991	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16458303	MGI
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15816869	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	15816869	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16458303	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	27830702	MGI
acts upstream of or within positive regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	24127566	MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29153991	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	29153991	MGI
acts upstream of or within protein localization to tricellular tight junction	IMP IMP: Inferred from mutant phenotype	24889144	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	24889144	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22441692	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22441692	MGI
acts upstream of or within response to cadmium ion	IGI IGI: Inferred from genetic interaction	16458303	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	15816869	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	15816869	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	27830702	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	29153991	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11884367	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11884367	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk9 Protein Structure

STKc_JNK

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 9

JNK/SAPK alpha	Jun kinase
MAP kinase 9	MAPK 9
c-Jun N-terminal kinase 2	protein kinase, mitogen-activated 9
stress-activated protein kinase JNK2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-148063	DB0614	98.80%	Unkown
HY-148061	DB1113	99.28%	Unkown
HY-RS08127	MAPK9 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08128	Mapk9 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08129	Mapk9 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk9	NCBI	NCBI:5601

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