2. Gene
  3. GDF10 - growth differentiation factor 10 Gene

GDF10 - growth differentiation factor 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BIP; BMP3B; BMP-3b

Gene ID: 2662 | Gene type: protein coding

About GDF10

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:47,300,197-47,313,577 (from NCBI)

This gene has 1 transcript (splice variant), 261 orthologues and 31 paralogues. Biased expression in lung (RPKM 8.6), fat (RPKM 5.4) and 12 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral Cancer. [provided by RefSeq, Jul 2016]

GDF10 Products(1)

mRNA Protein Name
NM_004962.5 NP_004953.1 growth/differentiation factor 10 preproprotein

GDF10 Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (88 - 141)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (374 - 478)

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  • 478 a.a.
Protein Preferred Names Protein Names

growth/differentiation factor 10

bone morphogenetic protein 3B

Recombinant GDF10 Proteins

Cat. No. Product Name Accession Purity
HY-P7332 BMP-3B/GDF10 Protein, Human (His) P55107 (Q369-R478) ≥95%

Related Diseases

Diseases Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts 1

Van Der Knaap Disease

Leukoencephalopathy With Swelling And Cysts

MLC1

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts

Lvm

Vl

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 1

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 1

Megalencephalic Leukoencephalopathy With Subcortical Cysts
Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05350 GDF10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GDF10 VGNC VGNC:72908
Rattus norvegicus GDF10 RGD RGD:621512
Canis familiaris GDF10 VGNC VGNC:41158
Bos taurus GDF10 VGNC VGNC:29299
Felis catus GDF10 VGNC VGNC:108137
Mus musculus GDF10 MGD MGI:95684
Others GDF10 NCBI