2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Smad Family

Smad Family

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SMAD proteins are a unique group of related intracellular proteins responsible for transducing the signal induced by transforming growth factor-β (TGF-β) superfamily into the nucleus. Signals are initiated upon binding of TGF-β superfamily members to cell-surface serine/threonine kinase receptors and are then propagated by Smads. Activation of Smads results in their translocation from the cytoplasm into the nucleus, where they activate or repress transcription together with transcription factors so as to regulate target gene expression.
Functional studies have demonstrated that Smads, which range from about 400 to 500 amino acids in length, can be grouped into three subfamilies, the receptor-regulated Smads (R-Smads, i.e. Smads1/2/3/5/8), the common Smads (co-Smads, i.e. Smad4) and the inhibitory Smads (I-Smads, i.e. Smads6/7), each of which plays a distinct role in the pathway. Specifically, ligand binding induces activation of TGF-β receptor complexes, which then directly phosphorylate (P) specific R-Smads. These R-Smads associate with the co-Smads Smad4 and then translocate to the nucleus, where they interact with a variety of DNA-binding partners to regulate gene expression. Conversely, the I-Smads served to dampen TGF-β signaling in a feedback manner through a variety of mechanisms.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P71323
    SMAD3 Protein, Human (Flag-His)

    Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3; SMAD3; MADH3

    		Human E. coli
    The SMAD3 protein acts as a receptor-regulated SMAD (R-SMAD), transducing signals from TGF-β and activin type 1 receptor kinase. After being activated by antigen-presenting cells, SMAD3 binds to the TRE element in the gene promoter and forms a complex with SMAD4 to activate transcription. SMAD3 Protein, Human (Flag-His) is the recombinant human-derived SMAD3 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag.
  • HY-P71324
    SMAD4 Protein, Human (His)

    Mothers Against Decapentaplegic Homolog 4; MAD Homolog 4; Mothers Against DPP Homolog 4; Deletion Target in Pancreatic Carcinoma 4; SMAD Family Member 4; SMAD 4; Smad4; hSMAD4; SMAD4; DPC4; MADH4

    		Human E. coli
    SMAD4 is a class of common mediator SMAD (Co-SMAD), which belongs to the dwarfin/SMAD family. It conducts cell signals through the SMAD4/TGF-β pathway and plays an important role in promoting bone development and tissue homeostasis. SMAD4 induces chondrogenesis of human bone marrow mesenchymal stem cells, and specifically targets stem cells to participate in self-renewal of hematopoietic stem cells. SMAD4 can also protect cell apoptosis and inhibit epithelial cell proliferation, showing antitumor effects. SMAD4 Protein, Human (His) has the 552 a.a. sequence (M1-D552), produced in E.coli with C-terminal 6*His-tag.
  • HY-P71536
    SMAD2 Protein, Human (His-SUMO)

    Drosophila, homolog of, MADR2; hMAD-2; HsMAD2; JV18; JV18-1; JV181; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers against DPP homolog 2; OTTHUMP00000163489; Sma- and Mad-related protein 2 MAD; SMAD 2; SMAD family member 2; SMAD2; SMAD2_HUMAN

    		Human E. coli
    SMAD2 protein, an R-SMAD, acts as a transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds TRE elements, regulating TGF-beta target genes. Forming a complex with SMAD4, it promotes transcription, positively regulating PDPK1 and showing potential tumor suppressor functions in colorectal carcinoma. SMAD2 interacts with various proteins, participating in signal transduction and transcriptional regulation. SMAD2 Protein, Human (His-SUMO) is the recombinant human-derived SMAD2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
  • HY-P73636
    SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST)

    Mothers against decapentaplegic homolog 3; mMad3; Smad3; Madh3

    		Rat; Mouse; Human Sf9 insect cells
    The SMAD3 protein is an R-SMAD that acts as an intracellular signal transducer activated by TGF-β and activin type 1 receptor kinase.It binds TRE elements and regulates TGF-β target genes.SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is the recombinant rat-derived SMAD3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P73637
    SMAD2 Protein, Mouse (sf9, His-GST)

    Mothers against decapentaplegic homolog 2; MAD homolog 2; hMAD-2; SMAD2; MADH2; MADR2

    		Mouse Sf9 insect cells
    SMAD2 protein interacts with multiple partners, such as CREB-binding protein (CBP), EP300, SNON, and others.These interactions contribute to diverse cellular processes, including TGF-beta signaling and transcriptional regulation.SMAD2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived SMAD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
  • HY-P74539
    SMAD5 Protein, Mouse (sf9, His-GST)

    Mothers against decapentaplegic homolog 5; Dwarfin-C; SMAD 5

    		Mouse Sf9 insect cells
    SMAD5 (dwarfin C, JV5-1, MAD5) is a receptor activated Smad (R-Smad) belonging to the dwarfin/SMAD family. SMAD5 protein is activated by TGF-β receptor type I and binds to SMAD4 to form a trimer active form. SMAD5 is involved in BMP signaling pathway, regulates osteogenesis and is related to embryonic development. SMAD5 can up-regulate Runx2 expression and target osteocalcin and alkaline phosphatase (ALP) to function. SMAD5 Protein, Mouse (sf9, His-GST) has 464 amino acids expressed by sf9 insect cells with N-terminal His- and GST-tag.
  • HY-P74540
    SMAD5 Protein, Mouse (sf9)

    Mothers against decapentaplegic homolog 5; Dwarfin-C; SMAD 5

    		Mouse Sf9 insect cells
    SMAD5 (dwarfin C, JV5-1, MAD5) is a receptor activated Smad (R-Smad) belonging to the dwarfin/SMAD family. SMAD5 protein is activated by TGF-β receptor type I and binds to SMAD4 to form a trimer active form. SMAD5 is involved in BMP signaling pathway, regulates osteogenesis and is related to embryonic development. SMAD5 can up-regulate Runx2 expression and target osteocalcin and alkaline phosphatase (ALP) to function. SMAD5 Protein, Mouse (sf9) has 464 amino acids expressed by sf9 insect cells with tag free.
Cat. No. Product Name Effect Purity