2. Gene
  3. GGT5 - gamma-glutamyltransferase 5 Gene

GGT5 - gamma-glutamyltransferase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GGL; GGT 5; GGTLA1; GGT-REL

Gene ID: 2687 | Gene type: protein coding

About GGT5

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,219,654-24,245,142 (from NCBI)

This gene has 6 transcripts (splice variants), 343 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 18.6), kidney (RPKM 15.2) and 24 other tissues.

Summary

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded Enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GGT5 Products(5)

mRNA Protein Name
NM_001099781.2 NP_001093251.1 glutathione hydrolase 5 proenzyme isoform 1
NM_001099782.2 NP_001093252.1 glutathione hydrolase 5 proenzyme isoform 3
NM_001302464.1 NP_001289393.1 glutathione hydrolase 5 proenzyme isoform 4
NM_001302465.1 NP_001289394.1 glutathione hydrolase 5 proenzyme isoform 5
NM_004121.5 NP_004112.2 glutathione hydrolase 5 proenzyme isoform 2

GGT5 Protein Structure

G_glu_transpept

G_glu_transpept: Gamma-glutamyltranspeptidase (59 - 581)

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  • 586 a.a.
Protein Preferred Names Protein Names

glutathione hydrolase 5 proenzyme

gamma-glutamyl cleaving enzyme

Recombinant GGT5 Proteins

Cat. No. Product Name Accession Purity
HY-P76361 GGT5 Protein, Human (HEK293, His) P36269-1/NP_004112.2 (S30-Y586) ≥95%

Related Diseases

Diseases Alias
Glutathionuria

Gamma-Glutamyltransferase Deficiency

Ggt Deficiency

Gtg Deficiency

Gamma-Glutamyltranspeptidase Deficiency

Glutathioninuria

Gamma-Glutamyl Transpeptidase Deficiency

Gamma-Glutamyl Transferase Deficiency

Ggt1 Deficiency

GLUTH
Capillariasis

Capillaria Infection

Enoplida Infections

Capillariasis Nos

Capillariosis
Retinitis Pigmentosa 43

RP43

Retinitis Pigmentosa, Type 43
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05404 GGT5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GGT5 MGD MGI:1346063
Rattus norvegicus GGT5 RGD RGD:2684
Bos taurus GGT5 VGNC VGNC:29344
Felis catus GGT5 VGNC VGNC:62540
Others GGT5 NCBI