Grm4 - glutamate receptor, metabotropic 4 Gene

Mus musculus

Also known as Gprc1d; mGluR4

Gene ID: 268934 | Gene type: protein coding

About Grm4

Chromosome 17: 27,641,361-27,740,377 reverse strand.GRCm39:CM001010.3

This gene has 8 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 4 phenotypes. Biased expression in cerebellum adult (RPKM 6.6), frontal lobe adult (RPKM 7.3) and 3 other tissues.

Summary

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Grm4 Products(4)

mRNA	Protein	Name
NM_001013385.2	NP_001013403.1	metabotropic glutamate receptor 4 isoform 2 precursor
NM_001379317.1	NP_001366246.1	metabotropic glutamate receptor 4 isoform 3
NM_001291045.2	NP_001277974.1	metabotropic glutamate receptor 4 isoform 1 precursor
NM_001360192.1	NP_001347121.1	metabotropic glutamate receptor 4 isoform 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	8815915	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	8815915	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	8815915	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	8815915	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	8815915	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cerebellar granule cell to Purkinje cell synapse	IDA IDA: Inferred from direct assay	32494600	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	8815915	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8815915	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	8815915	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI
is active in parallel fiber to Purkinje cell synapse	EXP EXP: Inferred from Experiment	8815915	MGI
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	8815915	MGI
is active in parallel fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	8815915	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	11906782	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm4 Protein Structure

PBP1_mGluR_groupIII

NCD3G

7tmC_mGluR4

0
200
400
600
800
912 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 4

G protein-coupled receptor GRM4

G protein-coupled receptor, family C, group 1, member D

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05828	GRM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05829	Grm4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05830	Grm4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm4	NCBI	NCBI:2914

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