Acvr1c - activin A receptor, type IC Gene

Mus musculus

Also known as ALK7; Alk-7; ACTR-IC; ACVRLK7; C230097P10

Gene ID: 269275 | Gene type: protein coding

About Acvr1c

Chromosome 2: 58,157,465-58,247,907 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 6 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 3.9), genital fat pad adult (RPKM 2.9) and 8 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; BMP Receptor binding activity; and activin binding activity. Acts upstream of or within several processes, including negative regulation of Insulin secretion; response to glucose; and response to Insulin. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Orthologous to human ACVR1C (Activin A receptor type 1C). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1c Products(2)

mRNA	Protein	Name
NM_001111030.1	NP_001104500.1	activin receptor type-1C isoform 1 precursor
NM_001033369.3	NP_001028541.1	activin receptor type-1C isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
NOT acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15485907	MGI
NOT acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15485907	MGI
acts upstream of insulin secretion	IMP IMP: Inferred from mutant phenotype	18480258	MGI
acts upstream of or within lipid storage	IMP IMP: Inferred from mutant phenotype	18480258	MGI
acts upstream of or within negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18480258	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	18480259	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	18480258	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	18480259	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr1c Protein Structure

Activin_recp

TGF_beta_GS

STKc_TGFbR1_ACVR1b_ACVR1c

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

activin receptor type-1C

activin receptor type IC

activin receptor-like kinase 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00242	ACVR1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00243	Acvr1c Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00244	Acvr1c Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acvr1c	NCBI	NCBI:130399

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