SIGLEC7 - sialic acid binding Ig like lectin 7 Gene

Homo sapiens

Also known as p75; QA79; AIRM1; CD328; AIRM-1; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1

Gene ID: 27036 | Gene type: protein coding

About SIGLEC7

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,142,301-51,153,526 (from NCBI)

This gene has 6 transcripts (splice variants), 79 orthologues and 16 paralogues. Broad expression in spleen (RPKM 7.6), appendix (RPKM 5.3) and 14 other tissues.

Summary

Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGLEC7 Products(3)

mRNA	Protein	Name
NM_001277201.2	NP_001264130.1	sialic acid-binding Ig-like lectin 7 isoform 3 precursor
NM_014385.4	NP_055200.1	sialic acid-binding Ig-like lectin 7 isoform 1 precursor
NM_016543.4	NP_057627.2	sialic acid-binding Ig-like lectin 7 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC7 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

sialic acid-binding Ig-like lectin 7

QA79 membrane protein

Recombinant SIGLEC7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71311	Siglec-7 Protein, Human (HEK293, His)	Q9Y286 (Q19-L353)	≥95%

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Iic

CDG2C	Congenital Disorder Of Glycosylation Type Iic
Leukocyte Adhesion Deficiency Type Ii	Cdg Iic
Cdgiic	Rambam-Hasharon Syndrome
Leukocyte Adhesion Deficiency, Type Ii	Lad2
Leukocyte Adhesion Deficiency 2	Cdg-Iic
Congenital Disorder Of Glycosylation, Type 2c	Rhs
Cdg Syndrome Type Iic	Lad-Ii
Rambam Hasharon Syndrome	Congenital Disorder Of Glycosylation 2c
Glycosylation, Congenital Disorder Of, Type Iic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70302	ST8 alpha-2,8-Sialyltransferase 6		/	Unkown
HY-RS12905	SIGLEC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIGLEC7	MGD	MGI:1932475

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