CACNG4 - calcium voltage-gated channel auxiliary subunit gamma 4 Gene

Homo sapiens

Gene ID: 27092 | Gene type: protein coding

About CACNG4

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:66,964,707-67,033,398 (from NCBI)

This gene has 1 transcript (splice variant), 257 orthologues and 5 paralogues. Biased expression in brain (RPKM 19.4), prostate (RPKM 8.2) and 1 other tissue.

Summary

The protein encoded by this gene is a type I transmembrane AMPA Receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a Calcium Channel gamma subunit. [provided by RefSeq, Dec 2010]

CACNG4 Products(1)

mRNA	Protein	Name
NM_014405.4	NP_055220.1	voltage-dependent calcium channel gamma-4 subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	21127204	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	21172611	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of L-type voltage-gated calcium channel complex	IDA IDA: Inferred from direct assay	21127204	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACNG4 Protein Structure

PMP22_Claudin

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

voltage-dependent calcium channel gamma-4 subunit

TARP gamma-4

Related Diseases

Diseases

Alias

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01812	CACNG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CACNG4	RGD	RGD:628804
Mus musculus	CACNG4	MGD	MGI:1859167
Macaca mulatta	CACNG4	VGNC	VGNC:104588
Bos taurus	CACNG4	VGNC	VGNC:26689
Felis catus	CACNG4	VGNC	VGNC:98776

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