PRELID1 - PRELI domain containing 1 Gene

Homo sapiens

Also known as PX19; PRELI; SBBI12; CGI-106

Gene ID: 27166 | Gene type: protein coding

About PRELID1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,303,799-177,306,949 (from NCBI)

This gene has 8 transcripts (splice variants), 339 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 60.0), small intestine (RPKM 55.2) and 25 other tissues.

Summary

This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

PRELID1 Products(2)

mRNA	Protein	Name
NM_001271828.2	NP_001258757.1	PRELI domain-containing protein 1, mitochondrial isoform 2 precursor
NM_013237.4	NP_037369.1	PRELI domain-containing protein 1, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to phosphatidic acid transfer activity	IMP IMP: Inferred from mutant phenotype	23931759	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21364629	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	21364629	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23931759	GOA
involved in negative regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	18945965	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	23931759	GOA
involved in positive regulation of T cell apoptotic process	IDA IDA: Inferred from direct assay	18945965	GOA
involved in positive regulation of cellular respiration	IDA IDA: Inferred from direct assay	21364629	GOA
involved in positive regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	18945965	GOA
involved in positive regulation of phospholipid transport	IDA IDA: Inferred from direct assay	23931759	GOA
involved in regulation of T cell differentiation	IDA IDA: Inferred from direct assay	18945965	GOA
involved in regulation of membrane lipid distribution	IDA IDA: Inferred from direct assay	23931759	GOA
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	21364629	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	21364629	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23931759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRELID1 Protein Structure

PRELI

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

PRELI domain-containing protein 1, mitochondrial

25 kDa protein of relevant evolutionary and lymphoid interest

Related Diseases

Diseases

Alias

Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma	Chronic Angle-Closure Glaucoma
Chronic Narrow Angle Glaucoma	Secondary Angle-Closure Glaucoma - Synechial

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11081	PRELID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRELID1	MGD	MGI:1913744
Rattus norvegicus	PRELID1	RGD	RGD:1308082
Macaca mulatta	PRELID1	VGNC	VGNC:84481
Canis familiaris	PRELID1	VGNC	VGNC:44955
Felis catus	PRELID1	VGNC	VGNC:97567
Bos taurus	PRELID1	VGNC	VGNC:33306

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