IL36B - interleukin 36 beta Gene

Homo sapiens

Also known as FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)

Gene ID: 27177 | Gene type: protein coding

About IL36B

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,022,089-113,052,867 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 7 paralogues. Biased expression in skin (RPKM 1.1) and esophagus (RPKM 0.5).

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL36B Products(2)

mRNA	Protein	Name
NM_014438.5	NP_055253.2	interleukin-36 beta isoform 1
NM_173178.3	NP_775270.1	interleukin-36 beta isoform 2

Protein Preferred Names

Protein Names

interleukin-36 beta

FIL1 eta

Recombinant IL36B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72545	IL-36 beta/IL-1F8 Protein, Human	Q9NZH7-2 (R5-E157)	≥95%
HY-P74803	IL-36 beta/IL-1F8 Protein, Human (His)	Q9NZH7-2 (K5-E157)	≥95%
HY-P74803AF	Animal-Free IL-36 beta/IL-1F8 Protein, Human (His)	Q9NZH7-2 (R5-E157)	≥95%

Related Diseases

Diseases

Alias

Impetigo Herpetiformis

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Miliaria Crystallina

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06760	IL36B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL36B	VGNC	VGNC:30157
Mus musculus	IL36B	MGD	MGI:1916927
Macaca mulatta	IL36B	VGNC	VGNC:73603
Rattus norvegicus	IL36B	RGD	RGD:1307847
Canis familiaris	IL36B	VGNC	VGNC:41984
Others	IL36B	NCBI

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