GPR78 - G protein-coupled receptor 78 Gene

Homo sapiens

Gene ID: 27201 | Gene type: protein coding

About GPR78

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,580,392-8,590,023 (from NCBI)

This gene has 7 transcripts (splice variants), 171 orthologues and 3 paralogues. Biased expression in placenta (RPKM 2.0), esophagus (RPKM 0.8) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an Orphan Receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GPR78 Products(1)

mRNA	Protein	Name
NM_080819.5	NP_543009.2	G-protein coupled receptor 78

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	17363172	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26940976	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17363172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR78 Protein Structure

7tm_1

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 78

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05735	GPR78 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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